Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice
Jose Luis Vazquez Martinez
- 23 February 2023
Source:
Highlights
- •-Chronic ethanol exposure increases brain atrophy in APP/PS1 mice.
- •-Chronic ethanol exposure increases the number of amyloid plaques in APP/PS1 brains.
- •-Chronic ethanol exposure dysregulates metabolism in APP/PS1 mice.
- •-Chronic ethanol exposure alters anxiety- and dementia-related behaviors in APP/PS1 mice.
- •-Acute ethanol increases interstitial fluid (ISF) amyloid-β 40 (Aβ40) but not Aβ42 levels in APP/PS1 mice during withdrawal
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