Jose Luis Vazquez Martinez

A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion

Jose Luis Vazquez Martinez - 10 August 2020

Source:

Tränkner, D., Boulet, A., Peden, E., Focht, R., Van Deren, D., & Capecchi, M. (2019). A microglia sublineage protects from sex-linked anxiety symptoms and obsessive compulsion. Cell reports29(4), 791-799.

 

Graphical Abstract

 

Highlights

 

•A microglia sublineage derived from Hoxb8-expressing precursors serves unique functions
•Dysfunction of Hoxb8-lineage microglia causes anxiety symptoms and obsessive compulsion
•Female sex hormones worsen the pathology caused by Hoxb8-lineage microglia dysfunction