Supervised Dosing with a Long-Acting Opioid Medication in the Management of Opioid Dependence

Trials challenge the need for the widely accepted policy of making opioid-dependent patients take their methadone or other opioid substitutes at the clinic or pharmacy, but ‘no difference’ findings may be due to the limitations of the research.

Also analysed for this entry is the largest and most informative randomised trial of supervised consumption. Conducted in England, it offered no support for routine supervision for three months, then recommended practice.